3-AP-Me

CAT: 0804-HY-138844-01Size: 1 mgDry Ice: NoHazardous: No
CAT#:0804-HY-138844-01Size:1 mg
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Description
3-AP-Me is a dimethyl derivative of the nucleotide reductase inhibitor 3-AP (SML0568) . 3-AP-Me can activate the endoplasmic reticulum (ER) stress pathway by promoting the phosphorylation of eIF2α and increasing the gene expression of transcription factors ATF4 and ATF6, leading to cell apoptosis. Additionally, 3-AP-Me can activate the stress kinases c-Jun N-terminal kinase (JNK) and p38 mitogen-activated protein kinases. 3-AP-Me also leads to the upregulation of the spliced mRNA variant XBP1, can be used in cancer research[1].
CAS Number
[1184391-57-8]
UNSPSC
12352005
Hazard Statement
H302
Target
Apoptosis; Eukaryotic Initiation Factor (eIF) ; JNK; p38 MAPK
Related Pathways
Apoptosis; Cell Cycle/DNA Damage; MAPK/ERK Pathway
Field of Research
Cancer
Smiles
NC1=CC=CN=C1/C=N/NC(N(C)C)=S
Molecular Formula
C9H13N5S
Molecular Weight
223.30
Precautions
P264-P270-P330-P501
References & Citations
[1]Robert Trondl, et al. Triapine and a more potent dimethyl derivative induce endoplasmic reticulum stress in cancer cells. Mol Pharmacol. 2014 Mar;85 (3) :451-9.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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