3-AP-Me

• Description:

  3-AP-Me is a dimethyl derivative of the nucleotide reductase inhibitor 3-AP (SML0568) . 3-AP-Me can activate the endoplasmic reticulum (ER) stress pathway by promoting the phosphorylation of eIF2α and increasing the gene expression of transcription factors ATF4 and ATF6, leading to cell apoptosis. Additionally, 3-AP-Me can activate the stress kinases c-Jun N-terminal kinase (JNK) and p38 mitogen-activated protein kinases. 3-AP-Me also leads to the upregulation of the spliced mRNA variant XBP1, can be used in cancer research[1].

• UNSPSC:

  12352005

• Hazard Statement:

  H302

• Target:

  Apoptosis; Eukaryotic Initiation Factor (eIF) ; JNK; p38 MAPK

• Related Pathways:

  Apoptosis; Cell Cycle/DNA Damage; MAPK/ERK Pathway

• Field of Research:

  Cancer

• Smiles:

  NC1=CC=CN=C1/C=N/NC(N(C)C)=S

• Molecular Formula:

  C9H13N5S

• Molecular Weight:

  223.30

• Precautions:

  P264-P270-P330-P501

• References & Citations:

  [1]Robert Trondl, et al. Triapine and a more potent dimethyl derivative induce endoplasmic reticulum stress in cancer cells. Mol Pharmacol. 2014 Mar;85 (3) :451-9.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  [1184391-57-8]