3′-Me Meayamycin D

CAT: 0931-T204847-01Size: 10 mgDry Ice: NoHazardous: No

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CAT#:0931-T204847-01Size:10 mg

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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Target

Others

Related Pathways

Others

Bioactivity

3’-Me Meayamycin D is a splice modulator that targets SF3B1 and PHF5A, affecting the pre-mRNA splicing process and downregulating MCL-1 expression. It inhibits the proliferation of cancer cell lines HCT116, SW48, A549, DMS53, and DMS114, with a GI50 range of 4.6-7.2 nM. In mice, it demonstrates good plasma stability with a half-life of 16 hours.

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C[C@H]1C[C@H]([C@H](O[C@H]1C/C=C(\C)/C=C/[C@@H]2[C@H]([C@@]3(CC(O2)(C)C)CO3)O)C)NC(=O)/C=C(/C)\[C@H](C)OCOC

Molecular Formula

C29H47NO7

Molecular Weight

521.686

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

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GTR19249812-01	3′-Me Meayamycin D
MBS5823477	Meayamycin D
GTR19274926-01	Meayamycin B
FP89152-01	Polysiloxanes di-Me, Me 3,3,3-trifluoropropyl
GTR19250452-01	3-AP-Me
HY-W013522	Me-PEG4-Me
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3′-Me Meayamycin D

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