SB-505124 (Standard)

• Description:

  SB-505124 (Standard) is the analytical standard of SB-505124. This product is intended for research and analytical applications. SB-505124 is a selective inhibitor of TGF-β Receptor type I receptors (ALK4, ALK5, ALK7), with IC50s of 129 nM and 47 nM for ALK4, ALK5, respectively, but it does not inhibit ALK1, 2, 3, or 6.

• UNSPSC:

  12352100

• Target:

  Reference Standards; TGF-β Receptor

• Related Pathways:

  Others; TGF-beta/Smad

• Field of Research:

  Cancer

• Smiles:

  CC1=CC=CC (C2=C (C3=CC=C (OCO4) C4=C3) N=C (C (C) (C) C) N2) =N1

• Molecular Formula:

  C20H21N3O2

• Molecular Weight:

  335.40

• References & Citations:

  [1]DaCosta Byfield S, et al. SB-505124 is a selective inhibitor of transforming growth factor-beta type I receptors ALK4, ALK5, and ALK7. Mol Pharmacol. 2004 Mar;65 (3) :744-52.|[2]Sutariya V, et al. Thermoreversible gel for delivery of receptor-like kinase 5 inhibitor SB-505124 for glaucoma filtration surgery. Pharm Dev Technol. 2013 Jul-Aug;18 (4) :957-62.|[3]Sapitro J, et al. Suppression of transforming growth factor-β effects in rabbit subconjunctival fibroblasts by receptor-like kinase 5 inhibitor. Mol Vis. 2010 Sep 16;16:1880-92.|[4]Marini KD, et al. Inhibition of activin signaling in lung adenocarcinoma increases the therapeutic index of platinum chemotherapy. Sci Transl Med. 2018 Jul 25;10 (451) . pii: eaat3504.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference Standards

• CAS Number:

  694433-59-5