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SB-505124 (Standard)

CAT: 0804-HY-13521R-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-13521R-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
SB-505124 (Standard) is the analytical standard of SB-505124. This product is intended for research and analytical applications. SB-505124 is a selective inhibitor of TGF-β Receptor type I receptors (ALK4, ALK5, ALK7), with IC50s of 129 nM and 47 nM for ALK4, ALK5, respectively, but it does not inhibit ALK1, 2, 3, or 6.
CAS Number
694433-59-5
UNSPSC
12352100
Target
Reference Standards; TGF-β Receptor
Related Pathways
Others; TGF-beta/Smad
Field of Research
Cancer
Smiles
CC1=CC=CC(C2=C(C3=CC=C(OCO4)C4=C3)N=C(C(C)(C)C)N2)=N1
Molecular Formula
C20H21N3O2
Molecular Weight
335.40
References & Citations
[1]DaCosta Byfield S, et al. SB-505124 is a selective inhibitor of transforming growth factor-beta type I receptors ALK4, ALK5, and ALK7. Mol Pharmacol. 2004 Mar;65 (3) :744-52.|[2]Sutariya V, et al. Thermoreversible gel for delivery of receptor-like kinase 5 inhibitor SB-505124 for glaucoma filtration surgery. Pharm Dev Technol. 2013 Jul-Aug;18 (4) :957-62.|[3]Sapitro J, et al. Suppression of transforming growth factor-β effects in rabbit subconjunctival fibroblasts by receptor-like kinase 5 inhibitor. Mol Vis. 2010 Sep 16;16:1880-92.|[4]Marini KD, et al. Inhibition of activin signaling in lung adenocarcinoma increases the therapeutic index of platinum chemotherapy. Sci Transl Med. 2018 Jul 25;10 (451) . pii: eaat3504.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards

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