Products for Research Use Only
RegisterLogin

Mitoxantrone-d8 (hydrochloride)

CAT: 0804-HY-13502AS1Size: 1 EachDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0804-HY-13502AS1Size:1 Each
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
Mitoxantrone-d8 (hydrochloride) (Mitozantrone-d8 (hydrochloride) ) is deuterium labeled Mitoxantrone (dihydrochloride) . Mitoxantrone dihydrochloride is a potent topoisomerase II inhibitor. Mitoxantrone dihydrochloride also inhibits protein kinase C (PKC) activity with an IC50 of 8.5 μM. Mitoxantrone dihydrochloride induces apoptosis of B-CLL (B-chronic lymphocytic leukaemia) cells. Mitoxantrone dihydrochloride shows antitumor activity[1][2][3][4]. Mitoxantrone dihydrochloride also has anti-orthopoxvirus activity with EC50s of 0.25 μM and and 0.8 μM for cowpox and monkeypox, respectively[5].
Product Name Alternative
Mitozantrone-d8 (hydrochloride) ; NSC 301739-d8 (hydrochloride)
UNSPSC
12352005
Target
Apoptosis; Endogenous Metabolite; Isotope-Labeled Compounds; Orthopoxvirus; PKC; Topoisomerase
Related Pathways
Anti-infection; Apoptosis; Cell Cycle/DNA Damage; Epigenetics; Metabolic Enzyme/Protease; Others; TGF-beta/Smad
Applications
COVID-19-anti-virus
Field of Research
Cancer; Infection
Smiles
O=C1C2=C(C(C3=C1C(NCCNC([2H])([2H])C([2H])([2H])O)=CC=C3NCCNC([2H])([2H])C([2H])([2H])O)=O)C(O)=CC=C2O.Cl
Molecular Formula
C22H21D8ClN4O6
Molecular Weight
488.99
References & Citations
[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216.|[2]Venza I, et al. Class II-specific histone deacetylase inhibitors MC1568 and MC1575 suppress IL-8 expression in human melanoma cells. Pigment Cell Melanoma Res. 2013 Mar;26 (2) :193-204.|[3]Fujimoto S, et al. Antitumor activity of mitoxantrone against murine experimental tumors: comparative analysis against various antitumor antibiotics. Cancer Chemother Pharmacol. 1982;8 (2) :157-62.|[4]Takeuchi N, et al. Inhibitory effect of mitoxantrone on activity of protein kinase C and growth of HL60 cells. J Biochem. 1992 Dec;112 (6) :762-7.|[5]Bellosillo B, et al. Mitoxantrone, a topoisomerase II inhibitor, induces apoptosis of B-chronic lymphocytic leukaemia cells. Br J Haematol. 1998 Jan;100 (1) :142-6.|[6]Sharon E Altmann, et al. Inhibition of cowpox virus and monkeypox virus infection by mitoxantrone. Antiviral Res. 2012 Feb;93 (2) :305-308.
Shipping Conditions
Room temperature
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported

Related Products

CatalogName
HY-13502SMitoxantrone-d8
HY-13502ASMitoxantrone-d8 (dihydrochloride)
HY-B0615AS-01Moricizine-d8 (Hydrochloride)
HY-B0193AS-01Prazosin-d8 (hydrochloride)
HY-13463BS-01Avatrombopag-d8 (hydrochloride)
HY-B0077S1-01Bendamustine-d8 (hydrochloride)
HY-13342SApatinib-d8 (hydrochloride)
HY-W713297Moroxydine (hydrochloride) -d8
HY-16746SLavamilast-d8 (hydrochloride)
HY-B0356S-01Ciprofloxacin-d8 (hydrochloride)

Alternative Products

CatalogName
M15709-01Mitoxantrone hydrochloride
A10596-50Mitoxantrone Hydrochloride 50mg
A10596-250Mitoxantrone Hydrochloride 250mg
A10596-100Mitoxantrone Hydrochloride 100mg
A10596-500Mitoxantrone Hydrochloride 500mg
CS-C-01034Prochlorperazine-d8 Hydrochloride (piperazine-d8)
CS-O-40397Trifluoperazine-d8 Hydrochloride
CS-O-03392Bendamustine-d8 Hydrochloride
C5074-01Ciprofloxacin-d8, Hydrochloride
TRC-D537502-2.5MGDoxazosin-d8 Hydrochloride

Popular Products