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Mitoxantrone-d8

CAT: 0804-HY-13502SSize: 1 mgDry Ice: NoHazardous: No
CAT#:0804-HY-13502SSize:1 mg
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Description
Mitoxantrone-d8 (mitozantrone-d8) is the deuterium labeled Mitoxantrone. Mitoxantrone is a topoisomerase II inhibitor and also inhibits protein kinase C (PKC) activity with an IC50 of 8.5 μM[1][2].
CAS Number
[1189974-82-0]
Product Name Alternative
Mitozantrone-d8; NSC 301739-d8
UNSPSC
12352005
Hazard Statement
H302-H315-H319-H335
Target
Isotope-Labeled Compounds; PKC; Topoisomerase
Type
Isotope-Labeled Compounds
Related Pathways
Cell Cycle/DNA Damage; Epigenetics; Others; TGF-beta/Smad
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Solubility
10 mM in DMSO
Smiles
N(CCNC(C(O)([2H])[2H])([2H])[2H])C1=C2C(=C(NCCNC(C(O)([2H])[2H])([2H])[2H])C=C1)C(=O)C=3C(C2=O)=C(O)C=CC3O
Molecular Formula
C22H20D8N4O6
Molecular Weight
452.53
Precautions
P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
References & Citations
[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216.|[2]Takeuchi N, et al. Inhibitory effect of mitoxantrone on activity of protein kinase C and growth of HL60 cells. J Biochem. 1992 Dec;112 (6) :762-7.|[3]Bellosillo B, et al. Mitoxantrone, a topoisomerase II inhibitor, induces apoptosis of B-chronic lymphocytic leukaemia cells. Br J Haematol. 1998 Jan;100 (1) :142-6.|[4]Vibet S, et al. Differential subcellular distribution of mitoxantrone in relation to chemosensitization in two human breast cancer cell lines. Drug Metab Dispos. 2007 May;35 (5) :822-8.|[5]Fujimoto S, et al. Antitumor activity of mitoxantrone against murine experimental tumors: comparative analysis against various antitumor antibiotics. Cancer Chemother Pharmacol. 1982;8 (2) :157-62.
Shipping Conditions
Room temperature
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported

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