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Quabodepistat-d7

CAT: 0804-HY-134940SSize: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-134940SSize:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Quabodepistat-d7 (OPC-167832-d7) is deuterium labeled Quabodepistat. Quabodepistat (OPC-167832) is a potent and orally active dprE1 inhibitor with?an IC50 of 0.258 μM. Quabodepistat has antituberculosis activity and can be used for the research of tuberculosis?caused by?Mycobacterium tuberculosis[1].
Product Name Alternative
OPC-167832-d7
UNSPSC
12352101
Target
Bacterial; Isotope-Labeled Compounds
Related Pathways
Anti-infection; Others
Applications
COVID-19-immunoregulation
Field of Research
Infection; Inflammation/Immunology
Smiles
O=C1NC2=C(C(OC[C@]3(O)[C@](O)([2H])C([2H])([2H])N(C4=C(F)C=C(Cl)C=C4F)C([2H])([2H])C3([2H])[2H])=CC=C2F)CC1
Molecular Formula
C21H13D7ClF3N2O4
Molecular Weight
463.89
References & Citations
[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216.|[2]Norimitsu Hariguchi, et al. OPC-167832, a Novel Carbostyril Derivative with Potent Antituberculosis Activity as a DprE1 Inhibitor.Antimicrob Agents Chemother. 2020 May 21;64 (6) :e02020-19.
Shipping Conditions
Room temperature
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported

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