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Bendroflumethiazide-d7

CAT: 0804-HY-B1363S1Size: 1 EachDry Ice: NoHazardous: No
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Description
Bendroflumethiazide-d7 (Bendrofluazide-d7) is deuterium labeled Bendroflumethiazide. Bendroflumethiazide (Bendrofluazide) is an orally available diuretic. Bendroflumethiazide inhibits the electroneutral sodium-chloride symporter located in the apical membrane of the early segment of the distal convoluted tubule and can effectively lower blood pressure. Bendroflumethiazide is used in the study of hypertension and edema. Bendroflumethiazide has an antidiuretic effect in diabetes insipidus[1][2][3].
Product Name Alternative
Bendrofluazide-d7
UNSPSC
12352005
Target
Isotope-Labeled Compounds; NKCC
Related Pathways
Membrane Transporter/Ion Channel; Others
Applications
Neuroscience-Neuromodulation
Field of Research
Cardiovascular Disease
Smiles
O=S(C1=C(C(F)(F)F)C=C(C2=C1)NC(C([2H])([2H])C3=C([2H])C([2H])=C([2H])C([2H])=C3[2H])NS2(=O)=O)(N)=O
Molecular Formula
C15H7D7F3N3O4S2
Molecular Weight
428.46
References & Citations
[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216.|[2]Tamargo J, et al. Diuretics in the treatment of hypertension. Part 1: thiazide and thiazide-like diuretics. Expert Opin Pharmacother. 2014 Mar;15 (4) :527-47.|[3]Grønbeck L, et al. Mechanism of antidiuresis caused by bendroflumethiazide in conscious rats with diabetes insipidus. Br J Pharmacol. 1998 Feb;123 (4) :737-45.
Shipping Conditions
Room temperature
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported

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