Products for Research Use Only
RegisterLogin

Dasatinib N-oxide (Standard)

CAT: 0804-HY-133794RSize: 1 EachDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0804-HY-133794RSize:1 Each
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
L-Ascorbic acid (GMP Like) (Standard) is the analytical standard of L-Ascorbic acid (GMP Like). This product is intended for research and analytical applications. L-Ascorbic acid (GMP Like) is the GMP Like class L-Ascorbic acid. L-Ascorbic acid (L-Ascorbate, Vitamin C), an electron donor, is an endogenous antioxidant agent. L-Ascorbic acid inhibits selectively Cav3.2 channels with an IC50 of 6.5 μM. L-Ascorbic acid is also a collagen deposition enhancer and an elastogenesis inhibitor[1][2][3]. L-Ascorbic acid exhibits anti-cancer effects through the generation of reactive oxygen species (ROS) and selective damage to cancer cells[4].
CAS Number
910297-52-8
UNSPSC
12352005
Target
Drug Metabolite; Reference Standards
Related Pathways
Metabolic Enzyme/Protease; Others
Field of Research
Cancer
Smiles
O=C(C1=CN=C(NC2=NC(C)=NC(N3CC[N+](CCO)([O-])CC3)=C2)S1)NC4=C(C)C=CC=C4Cl
Molecular Formula
C22H26ClN7O3S
Molecular Weight
504.00
References & Citations
[1]Christopher LJ, et, al. Metabolism and disposition of dasatinib after oral administration to humans. Drug Metab Dispos. 2008 Jul;36 (7) :1357-64.|[2]Furlong MT, et, al. A validated LC-MS/MS assay for the simultaneous determination of the anti-leukemic agent dasatinib and two pharmacologically active metabolites in human plasma: application to a clinical pharmacokinetic study. J Pharm Biomed Anal. 2012 Jan 25;58:130-5.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards

Chemical Information

N-(2-chloro-6-methylphenyl)-2-[[6-[4-(2-hydroxyethyl)-4-oxidopiperazin-4-ium-1-yl]-2-methylpyrimidin-4-yl]amino]-1,3-thiazole-5-carboxamide

Dasatinib n-oxide is an aromatic amide.

CAS Number910297-52-8
PubChem CID11854535
IUPAC NameN-(2-chloro-6-methylphenyl)-2-[[6-[4-(2-hydroxyethyl)-4-oxidopiperazin-4-ium-1-yl]-2-methylpyrimidin-4-yl]amino]-1,3-thiazole-5-carboxamide
Molecular FormulaC22H26ClN7O3S
Molecular Weight504.0
XLogP3.6
Topological Polar Surface Area150
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count9
Rotatable Bond Count7
Heavy Atom Count34
Formal Charge0
Complexity687
SMILES
CC1=C(C(=CC=C1)Cl)NC(=O)C2=CN=C(S2)NC3=CC(=NC(=N3)C)N4CC[N+](CC4)(CCO)[O-]
InChI
InChI=1S/C22H26ClN7O3S/c1-14-4-3-5-16(23)20(14)28-21(32)17-13-24-22(34-17)27-18-12-19(26-15(2)25-18)29-6-8-30(33,9-7-29)10-11-31/h3-5,12-13,31H,6-11H2,1-2H3,(H,28,32)(H,24,25,26,27)
InChIKey
UEFNEEZCTQCRAW-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of N-(2-chloro-6-methylphenyl)-2-[[6-[4-(2-hydroxyethyl)-4-oxidopiperazin-4-ium-1-yl]-2-methylpyrimidin-4-yl]amino]-1,3-thiazole-5-carboxamide
CAS: 910297-52-8
CID: 11854535
Formula: C22H26ClN7O3S
MW: 504.0
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight504.0
XLogP33.6
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count9
Rotatable Bond Count7
Exact Mass503.1506366
Monoisotopic Mass503.1506366
Topological Polar Surface Area150 Ų
Heavy Atom Count34
Formal Charge0
Complexity687
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Related Products

CatalogName
HY-133794-01Dasatinib N-oxide
HY-133794S-01Dasatinib N-oxide-d8
HY-107447R-01N-Deshydroxyethyl Dasatinib (Standard)
HY-10181R-01Dasatinib (Standard)
HY-10181BRDasatinib (monohydrate) (Standard)
HY-10181AR-01Dasatinib (hydrochloride) (Standard)
HY-17366R-01Clozapine N-oxide (Standard)
HY-133724RVardenafil N-oxide (Standard)
HY-116084R-01Trimethylamine N-oxide (Standard)
HY-135586RRaloxifene N-Oxide (Standard)

Alternative Products

CatalogName
TRC-D193610-5MGDasatinib N-Oxide
007528Dasatinib-d8 N-Oxide
AR-D06539-01Dasatinib N4-Oxide
T18750-01N-Deshydroxyethyl Dasatinib
RM-D192014-01Dasatinib Impurity N
RM-D192053-01N-nitroso Dasatinib

Popular Products