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Dasatinib N-oxide

CAT: 0804-HY-133794-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-133794-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Dasatinib N-oxide is a minor metabolite of Dasatinib. Dasatinib is a potent and orally active dual Src/Bcr-Abl inhibitor[1][2].
CAS Number
910297-52-8
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Drug Metabolite
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/dasatinib-n-oxide.html
Purity
99.27
Solubility
DMSO : 8.33 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
O=C(C1=CN=C(NC2=NC(C)=NC(N3CC[N+](CCO)([O-])CC3)=C2)S1)NC4=C(C)C=CC=C4Cl
Molecular Formula
C22H26ClN7O3S
Molecular Weight
504.00
Precautions
H302, H315, H319, H335
References & Citations
[1]Christopher LJ, et, al. Metabolism and disposition of dasatinib after oral administration to humans. Drug Metab Dispos. 2008 Jul;36 (7) :1357-64.|[2]Furlong MT, et, al. A validated LC-MS/MS assay for the simultaneous determination of the anti-leukemic agent dasatinib and two pharmacologically active metabolites in human plasma: application to a clinical pharmacokinetic study. J Pharm Biomed Anal. 2012 Jan 25;58:130-5.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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