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ARC 239 (Standard)

CAT: 0804-HY-12709RSize: 1 EachDry Ice: NoHazardous: No
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Description
ARC 239 (Standard) is the analytical standard of ARC 239. This product is intended for research and analytical applications. ARC 239 is an α2B/C-adrenergic receptor antagonist with pKi of 7.06 and 6.95 for rat kidney α2B and human α2C, respectively. ARC 239 also inhibits 5-HT1A receptor with a Ki of 63.1 nM[1][2].
CAS Number
67339-62-2
UNSPSC
12352100
Target
5-HT Receptor; Adrenergic Receptor; Reference Standards
Related Pathways
GPCR/G Protein; Neuronal Signaling; Others
Field of Research
Neurological Disease
Smiles
O=C1N(CCN2CCN(C3=CC=CC=C3OC)CC2)C(C(C)(C)C4=C1C=CC=C4)=O
Molecular Formula
C24H29N3O3
Molecular Weight
407.51
References & Citations
[1]K T Gavin, et al. Alpha 2C-adrenoceptors mediate contractile responses to noradrenaline in the human saphenous vein. Naunyn Schmiedebergs Arch Pharmacol. 1997 Mar;355 (3) :406-11. |[2]J J Meana, et al. The subtype-selective alpha 2-adrenoceptor antagonists BRL 44408 and ARC 239 also recognize 5-HT1A receptors in the rat brain. Eur J Pharmacol. 1996 Oct 3;312 (3) :385-8.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards

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