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Pittsburgh Compound B

CAT: 0804-HY-126192-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-126192-01Size:5 mg
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Description
Pittsburgh Compound B (PiB) is a PET tracer for Aβ deposition in Alzheimer's disease (AD), with high affinity and specificity. Through click chemistry modification (introducing a PEG3 linker and an alkyne group at the 6-hydroxy position of Pittsburgh Compound B to generate a clickable Pittsburgh Compound B derivative, followed by covalent conjugation with azide-labeled fluorescent dyes or affinity tags via copper-catalyzed azide-alkyne cycloaddition (CuAAC) ), Pittsburgh Compound B and its conjugates can be used for fluorescence imaging, ultrastructural studies, and the enrichment and characterization of Aβ complexes. Pittsburgh Compound B holds great potential in Alzheimer's disease research[1].
CAS Number
566169-93-5
Product Name Alternative
PiB; 6-OH-BTA-1
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H332, H335
Target
Amyloid-β
Related Pathways
Neuronal Signaling
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Purity
98.0
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
OC1=CC=C2N=C(SC2=C1)C3=CC=C(C=C3)NC
Molecular Formula
C14H12N2OS
Molecular Weight
256.33
Precautions
H302, H315, H319, H332, H335
References & Citations
[1]Diner I, et al. Generation of Clickable Pittsburgh Compound B for the Detection and Capture of β-Amyloid in Alzheimer's Disease Brain. Bioconjug Chem. 2017 Oct 18;28 (10) :2627-2637.|[2]Diner I, et al. Generation of Clickable Pittsburgh Compound B for the Detection and Capture of β-Amyloid in Alzheimer's Disease Brain. Bioconjug Chem. 2017 Oct 18;28 (10) :2627-2637.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light, stored under nitrogen)
Scientific Category
Reference compound1
Clinical Information
Phase 4

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