XL-784

• Description:

  XL-784 is a selective matrix metalloproteinases (MMP) inhibitor, with IC50s of ~1900, 0.81, 120, 10.8, 18, 0.56 nM for MMP-1, MMP-2, MMP-3, MMP-8, MMP-9, MMP-13, respectively.

• UNSPSC:

  12352005

• Target:

  MMP

• Type:

  Reference compound

• Related Pathways:

  Metabolic Enzyme/Protease

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Cardiovascular Disease

• Assay Protocol:

  https://www.medchemexpress.com/XL-784.html

• Purity:

  98.25

• Solubility:

  DMSO : ≥ 110 mg/mL

• Smiles:

  O=C(N1CC(C(N[O-])=O)N(S(=O)(C2=CC(F)=C(OC3=CC=C(Cl)C=C3)C(F)=C2)=O)CC1)OCCOC.[0.5Mg2+]

• Molecular Formula:

  C21H21ClF2N3O8S-

• Molecular Weight:

  548.92

• References & Citations:

  [1]Williams JM, et al. Evaluation of metalloprotease inhibitors on hypertension and diabetic nephropathy. Am J Physiol Renal Physiol. 2011 Apr;300 (4) :F983-98.|[2]Ennis T, et al. Effect of novel limited-spectrum MMP inhibitor XL784 in abdominal aortic aneurysms. J Cardiovasc Pharmacol Ther. 2012 Dec;17 (4) :417-26.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  4°C (Powder, sealed storage, away from moisture)

• Scientific Category:

  Reference compound1

• Clinical Information:

  Phase 2

• Isoform:

  MMP-1; MMP-13; MMP-2; MMP-3; MMP-8; MMP-9

• CAS Number:

  [1224964-36-6]