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JNJ-42905343

CAT: 0804-HY-124133Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-124133Size:1 Each
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Description
JNJ-42905343 is an orally active and highly selective prolyl hydroxylase (PHD1/2/3) inhibitor with pKI values of 8.07, 7.48 and 7.27 for PHD1, PHD2 and PHD3, respectively. JNJ-42905343 is promising for research of functional iron deficiency (FID) and anemia of chronic disease (ACD) [1].
CAS Number
1238689-36-5
UNSPSC
12352005
Target
HIF/HIF Prolyl-Hydroxylase
Related Pathways
Metabolic Enzyme/Protease
Applications
Neuroscience-Neuromodulation
Field of Research
Cardiovascular Disease
Smiles
O=C(C1=CN(C(NC2=C3C=C(OC4=C(C)C=CC=C4C)C(F)=C2)=NC3=O)N=C1)O
Molecular Formula
C20H15FN4O4
Molecular Weight
394.36
References & Citations
[1]Barrett TD, et al. Prolyl hydroxylase inhibition corrects functional iron deficiency and inflammation-induced anaemia in rats. Br J Pharmacol. 2015 Aug;172 (16) :4078-88.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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