GSK484

CAT: 0804-HY-123606-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0804-HY-123606-01Size:5 mg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
GSK484, a chemical probe, is a PAD4 inhibitor. GSK484 reduces inflammation and joint destruction in CIA mouse models. GSK484 inhibits TNF-α expression and reverses Erastin-induced gut dysbiosis. GSK484 can be used in rheumatoid arthritis (RA) research[1].
CAS Number
[1652629-23-6]
UNSPSC
12352005
Target
Protein Arginine Deiminase
Related Pathways
Epigenetics
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Purity
99.14
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
O=C(N1C[C@H](N)[C@H](O)CC1)C2=CC(OC)=C3C(N=C(C(N4CC5CC5)=CC6=C4C=CC=C6)N3C)=C2
Molecular Formula
C27H31N5O3
Molecular Weight
473.57
References & Citations
[1]Zhu X, et al. Ferroptosis Induces gut microbiota and metabolic dysbiosis in Collagen-Induced arthritis mice via PAD4 enzyme. Gene. 2025 Feb 5;936:149106.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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