GSK484

• Description :

  GSK484, a chemical probe, is a PAD4 inhibitor. GSK484 reduces inflammation and joint destruction in CIA mouse models. GSK484 inhibits TNF-α expression and reverses Erastin-induced gut dysbiosis. GSK484 can be used in rheumatoid arthritis (RA) research[1].

• CAS Number :

  [1652629-23-6]

• UNSPSC :

  12352005

• Target :

  Protein Arginine Deiminase

• Related Pathways :

  Epigenetics

• Applications :

  COVID-19-immunoregulation

• Field of Research :

  Inflammation/Immunology

• Purity :

  99.14

• Solubility :

  DMSO : 50 mg/mL (ultrasonic)

• Smiles :

  O=C(N1C[C@H](N)[C@H](O)CC1)C2=CC(OC)=C3C(N=C(C(N4CC5CC5)=CC6=C4C=CC=C6)N3C)=C2

• Molecular Formula :

  C27H31N5O3

• Molecular Weight :

  473.57

• References & Citations :

  [1]Zhu X, et al. Ferroptosis Induces gut microbiota and metabolic dysbiosis in Collagen-Induced arthritis mice via PAD4 enzyme. Gene. 2025 Feb 5;936:149106.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported