GSK789

CAT: 0804-HY-138623Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-138623Size:1 Each
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Description
GSK789, a chemical probe, is an effective, cell-permeable, and highly selective inhibitor of the BET family first bromodomain (BD1), with antitumor and immunomodulatory effects[1]
CAS Number
[2540591-06-6]
UNSPSC
12352005
Target
Epigenetic Reader Domain
Type
Reference compound
Related Pathways
Epigenetics
Applications
COVID-19-immunoregulation
Field of Research
Cancer; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/gsk789.html
Solubility
10 mM in DMSO
Smiles
O=C([C@@H]1CN(C)CC[C@H]1NC2=C3NC(C(C)=CC3=C(C4=CC=CO4)C=N2)=O)NC5CCCCC5
Molecular Formula
C26H33N5O3
Molecular Weight
463.57
References & Citations
[1]Watson RJ, et al. GSK789: A Selective Inhibitor of the First Bromodomains (BD1) of the Bromo and Extra Terminal Domain (BET) Proteins. J Med Chem. 2020 Sep 10;63 (17) :9045-9069.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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