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GSK180

CAT: 0804-HY-112179-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-112179-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
GSK180 is a selective, competitive, and potent inhibitor of kynurenine-3-monooxygenase (KMO), a key enzyme of tryptophan metabolism (IC50, ~6 nM), but shows negligible activity against other enzymes on the tryptophan pathway. GSK180 rapidly changes levels of kynurenine pathway metabolites, and acts as a useful tool to probe the therapeutic potential of KMO inhibition[1].
CAS Number
1799725-26-0
UNSPSC
12352005
Target
KMO
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/gsk180.html
Concentration
10mM
Purity
98.34
Solubility
DMSO : 250 mg/mL (ultrasonic)
Smiles
O=C(O)CCN1C(OC2=CC(Cl)=C(Cl)C=C12)=O
Molecular Formula
C10H7Cl2NO4
Molecular Weight
276.07
References & Citations
[1]Mole DJ, et al. Kynurenine-3-monooxygenase inhibition prevents multiple organ failure in rodent models of acute pancreatitis. Nat Med. 2016 Feb;22 (2) :202-9.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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