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AZD2836

CAT: 0804-HY-123536Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-123536Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
AZD2836 (A-831) is a 4-aminopyrazolone compound with anti-HCV activity. AZD2836 inhibits the activity of the host cell kinase PI4KIIIα, causing metabolic disorder of the cell membrane component PI4P that is necessary for viral replication. In the HCV subgenomic replicon cell model, the EC50 values of AZD2836 for genotype 1b (Con1 strain) and genotype 1a (Lemon strain) are 270 nM and 550 nM, respectively[1][2].
CAS Number
944278-62-0
Product Name Alternative
A-831
UNSPSC
12352005
Target
HCV; PI4K
Related Pathways
Anti-infection; PI3K/Akt/mTOR
Field of Research
Infection
Smiles
COC(C=CC(C(C=C12)=CC=C1N=CN=C2NC(C=C3)=CC=C3N4N=CN=C4)=C5)=C5OC
Molecular Formula
C24H20N6O2
Molecular Weight
424.45
References & Citations
[1]Bianco A, et al. Metabolism of phosphatidylinositol 4-kinase IIIα-dependent PI4P Is subverted by HCV and is targeted by a 4-anilino quinazoline with antiviral activity. PLoS pathogens. 2012 Mar 8;8 (3) :e1002576.|[2]Schmitz U, Tan SL. NS5A-from obscurity to new target for HCV therapy. Recent patents on anti-infective drug discovery. 2008 Jun 1;3 (2) :77-92.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
PI4KIIIα

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