AZD8233 (sodium)

• UNSPSC Description:

  AZD8233 sodium, a liver-targeting antisense oligonucleotide (ASO), inhibits subtilisin/kexin type 9 (PCSK9) protein synthesis. AZD8233 sodium increases the available LDL receptors by reducing PCSK9 levels, thereby clearing LDL from the blood and decreasing LDL-C levels.

• Target Antigen:

  PCSK9

• Type:

  Oligonucleotides

• Related Pathways:

  Metabolic Enzyme/Protease

• Applications:

  Metabolism-protein/nucleotide metabolism

• Field of Research:

  Metabolic Disease

• Assay Protocol:

  https://www.medchemexpress.com/azd8233-sodium.html

• Solubility:

  10 mM in H2O

• Smiles:

  [AZD8233 (sodium)]

• References & Citations:

  [1]Li XQ, Elebring M, Dahlén A, Weidolf L. In Vivo Metabolite Profiles of an N-Acetylgalactosamine-Conjugated Antisense Oligonucleotide AZD8233 Using Liquid Chromatography High-Resolution Mass Spectrometry: A Cross-Species Comparison in Animals and Humans. Drug Metab Dispos. 2023;51(10):1350-1361. doi:10.1124/dmd.123.001370

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported