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AZD2716

CAT: 0804-HY-120078-01Size: 1 mgDry Ice: NoHazardous: No
CAT#:0804-HY-120078-01Size:1 mg
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Description
AZD2716 is a selective sPLA2 (secretory phospholipase A2) inhibitor. AZD2716 significantly reduces the production of pro-inflammatory lipids by inhibiting sPLA2-IIa (IC50 = 10 nM), sPLA2-V (IC50 = 40 nM), and sPLA2-X (IC50 = 400 nM), thereby decreasing macrophage activation and foam cell formation. AZD2716 is promising for studying mechanisms related to atherosclerosis and inflammatory diseases associated with sPLA2[1].
CAS Number
[1845753-81-2]
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Phospholipase
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/azd2716.html
Purity
99.9
Solubility
DMSO : 10 mg/mL (ultrasonic; warming)
Smiles
NC(C1=C(C2=CC(C[C@@H](C)C(O)=O)=CC=C2)C=C(C=C1)CC3=CC=CC=C3)=O
Molecular Formula
C24H23NO3
Molecular Weight
373.44
Precautions
H302, H315, H319, H335
References & Citations
[1]Karlsson S, et al. An enantioselective hydrogenation of an alkenoic acid as a key step in the synthesis of AZD2716[J]. Organic Process Research & Development, 2016, 20 (2) : 262-269.|[2]Giordanetto F, et al. Discovery of AZD2716: A Novel Secreted Phospholipase A2 (sPLA2) Inhibitor for the Treatment of Coronary Artery Disease. ACS Med Chem Lett. 2016 Aug 9;7 (10) :884-889.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Phospholipase A

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