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(Rac) -AZD3839

CAT: 0804-HY-103268-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-103268-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
(Rac) -AZD3839 is an orally active beta-amyloid precursor protein cleaving enzyme (BACE1) inhibitor that is blood-brain barrier-permeable. (Rac) -AZD3839 has an affinity for the human ether-a-go-go related gene (hERG) ion channel. (Rac) -AZD3839 can be used in the research of Alzheimer's disease[1].
CAS Number
1227163-56-5
UNSPSC
12352005
Hazard Statement
H315-H319-H320
Target
Potassium Channel
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/rac-azd3839.html
Solubility
10 mM in DMSO
Smiles
NC1=NC(C2=CC(C(F)(F)F)=NC=C2)(C3=CC=CC(C4=CN=CN=C4)=C3)C5=C1C(F)=CC=C5
Molecular Formula
C24H15F4N5
Molecular Weight
449.40
Precautions
P264-P280-P302+P352-P305+P351+P338-P362
References & Citations
[1]Britt-Marie Swahn, et, al. Design and synthesis of β-site amyloid precursor protein cleaving enzyme (BACE1) inhibitors with in vivo brain reduction of β-amyloid peptides. J Med Chem 2012, 55, 21.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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