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FUB 349

CAT: 0804-HY-123278Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-123278Size:1 Each
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Description
FUB 349 (Compound 8) is a selective Aromatase inhibitor with an IC50 of 12 μM. FUB 349 is also a H3 receptor antagonist with Kis of 12 and 2.1 nM for rH3R and hH3R, respectively. FUB 349 can be used for neurological diseases such as cognitive impairment research[1][2].
CAS Number
184023-52-7
UNSPSC
12352005
Target
Cytochrome P450; Histamine Receptor
Related Pathways
GPCR/G Protein; Immunology/Inflammation; Metabolic Enzyme/Protease; Neuronal Signaling
Field of Research
Neurological Disease
Smiles
C1(CCCCC2=CC=CC=C2)=CN=CN1
Molecular Formula
C13H16N2
Molecular Weight
200.28
References & Citations
[1]Karjalainen A, et al. Synthesis of new potent and selective aromatase inhibitors based on long-chained diarylalkylimidazole and diarylalkyltriazole molecule skeletons. Eur J Pharm Sci. 2000 Aug;11 (2) :109-31. |[2]Ligneau X, et al. Distinct pharmacology of rat and human histamine H (3) receptors: role of two amino acids in the third transmembrane domain. Br J Pharmacol. 2000 Dec;131 (7) :1247-50.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Aromatase/CYP19A1; H3 Receptor

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