Ch-319

• Description:

  Ch-319 is a Triphenyltin (IV) carboxylate derivative. Ch-319 reduces androgen receptor expression, AKT and PRAS40 phosphorylation levels, and increases FOXO3a expression. Ch-319 increases Apoptosis. Ch-319 can be used in the research of prostate cancer[1].

• UNSPSC:

  12352005

• Target:

  Akt; Androgen Receptor; Apoptosis; Drug Derivative

• Related Pathways:

  Apoptosis; Others; PI3K/Akt/mTOR; Vitamin D Related/Nuclear Receptor

• Field of Research:

  Cancer

• Smiles:

  O=C(O[Sn](C1=CC=CC=C1)(C2=CC=CC=C2)C3=CC=CC=C3)C4=CC=CC=C4C(NCC5=CC=CC=C5)=O

• Molecular Formula:

  C33H27NO3Sn

• Molecular Weight:

  604.28

• References & Citations:

  [1]Waseem D, et al. Triphenylstannyl 2- (benzylcarbamoyl) benzoate (Ch-319) modulates AKT/FOXO3a signaling and inhibits progression of prostate cancer. Cancer Research, 2018, 78 (13_Supplement) : 688-688.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  [2589088-07-1]