CH-223191

• Description :

  CH-223191 is a potent and specific antagonist of aryl hydrocarbon receptor (AhR) . CH-223191 inhibits TCDD-mediated nuclear translocation and DNA binding of AhR, and inhibits TCDD-induced luciferase activity with an IC50 of 0.03 μM[1].

• UNSPSC :

  12352005

• Hazard Statement :

  H302

• Target :

  Aryl Hydrocarbon Receptor

• Type :

  Reference compound

• Related Pathways :

  Immunology/Inflammation

• Applications :

  Cancer-programmed cell death

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/CH-223191.html

• Purity :

  99.96

• Solubility :

  DMSO : ≥ 100 mg/mL

• Smiles :

  O=C(C1=CC=NN1C)NC2=CC=C(/N=N/C3=CC=CC=C3C)C=C2C

• Molecular Formula :

  C19H19N5O

• Molecular Weight :

  333.39

• Precautions :

  H302

• References & Citations :

  [1]Kim SH, et al. Novel compound 2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazo-phenyl) -amide (CH-223191) prevents 2,3,7,8-TCDD-induced toxicity by antagonizing the aryl hydrocarbon receptor. Mol Pharmacol. 2006 Jun;69 (6) :1871-8. Epub 2006 Mar 15.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [301326-22-7]