CH-223191

• Description:

  CH-223191 is a potent and specific antagonist of aryl hydrocarbon receptor (AhR) . CH-223191 inhibits TCDD-mediated nuclear translocation and DNA binding of AhR, and inhibits TCDD-induced luciferase activity with an IC50 of 0.03 μM[1].

• UNSPSC:

  12352005

• Hazard Statement:

  H302

• Target:

  Aryl Hydrocarbon Receptor

• Type:

  Reference compound

• Related Pathways:

  Immunology/Inflammation

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/CH-223191.html

• Purity:

  99.96

• Solubility:

  DMSO : ≥ 100 mg/mL

• Smiles:

  O=C(C1=CC=NN1C)NC2=CC=C(/N=N/C3=CC=CC=C3C)C=C2C

• Molecular Formula:

  C19H19N5O

• Molecular Weight:

  333.39

• Precautions:

  H302

• References & Citations:

  [1]Kim SH, et al. Novel compound 2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazo-phenyl) -amide (CH-223191) prevents 2,3,7,8-TCDD-induced toxicity by antagonizing the aryl hydrocarbon receptor. Mol Pharmacol. 2006 Jun;69 (6) :1871-8. Epub 2006 Mar 15.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  301326-22-7