CB 3705

• Description :

  CB 3705 is a dihydrofolate reductase (DHFR) and thymidylate synthetase (TS) inhibitor. CB 3705 inhibits L1210 cells and mutant L1210 cell line (L1210:C15) with ID50s of 4.77 μM and 408 μM, respectively[1][2].

• UNSPSC :

  12352005

• Target :

  Dihydrofolate reductase (DHFR) ; Thymidylate Synthase

• Related Pathways :

  Apoptosis; Metabolic Enzyme/Protease

• Applications :

  Cancer-programmed cell death

• Field of Research :

  Cancer

• Smiles :

  O=C(O)CC[C@@H](C(O)=O)NC(C1=CC=C(NCC2=CC3=C(NC(N)=NC3=O)C=C2)C=C1)=O

• Molecular Formula :

  C21H21N5O6

• Molecular Weight :

  439.42

• References & Citations :

  [1]Calvert AH, et al. Quinazoline antifolates with dual biochemical loci of action. Biochemical and biological studies directed towards overcoming methotrexate resistance. Eur J Cancer (1965) . 1980 May;16 (5) :713-22. |[2]Jackman AL, et al. Increased thymidylate synthase in L1210 cells possessing acquired resistance to N10-propargyl-5,8-dideazafolic acid (CB3717) : development, characterization, and cross-resistance studies. Cancer Res. 1986 Jun;46 (6) :2810-5.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [5854-11-5]