Pitolisant (Standard)

CAT: 0804-HY-12199R-02Size: 10 mgDry Ice: NoHazardous: No

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CAT#:0804-HY-12199R-02Size:10 mg

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Description

Pitolisant (Standard) is the analytical standard of Pitolisant. This product is intended for research and analytical applications. Pitolisant is a potent and selective nonimidazole inverse agonist at the recombinant human histamine H3 receptor (Ki=0.16 nM) .

CAS Number

362665-56-3

UNSPSC

12352100

Target

Histamine Receptor; Reference Standards

Related Pathways

GPCR/G Protein; Immunology/Inflammation; Neuronal Signaling; Others

Field of Research

Neurological Disease; Endocrinology

Smiles

ClC1=CC=C(CCCOCCCN2CCCCC2)C=C1

Molecular Formula

C17H26ClNO

Molecular Weight

295.85

References & Citations

[1]Ligneau X, et al. BF2.649 [1-{3-[3- (4-Chlorophenyl) propoxy]propyl}piperidine, hydrochloride], a nonimidazole inverse agonist/antagonist at the human histamine H3 receptor: Preclinical pharmacology. J Pharmacol Exp Ther. 2007 Jan;320 (1) :365-75.|[2]Dudek M, et al. H3 histamine receptor antagonist pitolisant reverses some subchronic disturbances induced by olanzapine in mice. Metab Brain Dis. 2016 Oct;31 (5) :1023-9.|[3]Uguen M, et al. Preclinical evaluation of the abuse potential of Pitolisant, a histamine H? receptor inverse agonist/antagonist compared with Modafinil. Br J Pharmacol. 2013 Jun;169 (3) :632-44.

Shipping Conditions

Room temperature

Scientific Category

Reference Standards

Chemical Information

Pitolisant

Pitolisant is an organochlorine compound.

CAS Number	362665-56-3
PubChem CID	9948102
IUPAC Name	1-[3-[3-(4-chlorophenyl)propoxy]propyl]piperidine
Molecular Formula	C17H26ClNO
Molecular Weight	295.8
XLogP	4.3
Topological Polar Surface Area	12.5
Hydrogen Bond Donor Count	0
Hydrogen Bond Acceptor Count	2
Rotatable Bond Count	8
Heavy Atom Count	20
Formal Charge	0
Complexity	235

SMILES

C1CCN(CC1)CCCOCCCC2=CC=C(C=C2)Cl

InChI

InChI=1S/C17H26ClNO/c18-17-9-7-16(8-10-17)6-4-14-20-15-5-13-19-11-2-1-3-12-19/h7-10H,1-6,11-15H2

InChIKey

NNACHAUCXXVJSP-UHFFFAOYSA-N

Chemical Structure

2D Structure

CAS: 362665-56-3

CID: 9948102

Formula: C17H26ClNO

MW: 295.8

Interactive 3D Structure

Loading 3D structure...

View on PubChem Raw 3D data

Computed Properties

Property	Value
Molecular Weight	295.8
XLogP3	4.3
Hydrogen Bond Donor Count	0
Hydrogen Bond Acceptor Count	2
Rotatable Bond Count	8
Exact Mass	295.1702921
Monoisotopic Mass	295.1702921
Topological Polar Surface Area	12.5 Å²
Heavy Atom Count	20
Formal Charge	0
Complexity	235
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently-Bonded Unit Count	1
Compound Is Canonicalized	Yes

Related Products

Catalog	Name
HY-12199BR-01	Pitolisant (hydrochloride) (Standard)
HY-12199-01	Pitolisant
HY-12199S	Pitolisant-d10
HY-12199B-01	Pitolisant (hydrochloride)
HY-12199A	Pitolisant (oxalate)
HY-12199S1	Pitolisant-d6
HY-12199BS	Pitolisant-d5 (hydrochloride)
HY-P2274R	Argifin (Standard)
HY-N9362R	Emodinanthrone (Standard)
HY-N7948R	Isomaltotetraose (Standard)

Alternative Products

Catalog	Name
BA5401-50	Pitolisant
A3727-5.1	Pitolisant hydrochloride
319900	Pitolisant HCl
T12491-01	Pitolisant oxalate

Pitolisant (Standard)

Chemical Information

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