Pitolisant

• Description :

  Pitolisant is a potent and selective nonimidazole inverse agonist at the recombinant human histamine H3 receptor (Ki=0.16 nM) .

• Product Name Alternative :

  Tiprolisant

• UNSPSC :

  12352005

• Hazard Statement :

  H302, H315, H319, H335

• Target :

  Histamine Receptor

• Type :

  Reference compound

• Related Pathways :

  GPCR/G Protein; Immunology/Inflammation; Neuronal Signaling

• Field of Research :

  Neurological Disease; Endocrinology

• Assay Protocol :

  https://www.medchemexpress.com/pitolisant.html

• Purity :

  99.73

• Solubility :

  DMSO : 200 mg/mL (ultrasonic)

• Smiles :

  ClC1=CC=C(CCCOCCCN2CCCCC2)C=C1

• Molecular Formula :

  C17H26ClNO

• Molecular Weight :

  295.85

• Precautions :

  H302, H315, H319, H335

• References & Citations :

  [1]Ligneau X, et al. BF2.649 [1-{3-[3- (4-Chlorophenyl) propoxy]propyl}piperidine, hydrochloride], a nonimidazole inverse agonist/antagonist at the human histamine H3 receptor: Preclinical pharmacology. J Pharmacol Exp Ther. 2007 Jan;320 (1) :365-75.|[2]Dudek M, et al. H3 histamine receptor antagonist pitolisant reverses some subchronic disturbances induced by olanzapine in mice. Metab Brain Dis. 2016 Oct;31 (5) :1023-9.|[3]Uguen M, et al. Preclinical evaluation of the abuse potential of Pitolisant, a histamine H? receptor inverse agonist/antagonist compared with Modafinil. Br J Pharmacol. 2013 Jun;169 (3) :632-44.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  Launched

• Isoform :

  H3 Receptor

• CAS Number :

  [362665-56-3]