Pitolisant

• Description:

  Pitolisant is a potent and selective nonimidazole inverse agonist at the recombinant human histamine H3 receptor (Ki=0.16 nM) .

• Product Name Alternative:

  Tiprolisant

• UNSPSC:

  12352005

• Hazard Statement:

  H302, H315, H319, H335

• Target:

  Histamine Receptor

• Type:

  Reference compound

• Related Pathways:

  GPCR/G Protein; Immunology/Inflammation; Neuronal Signaling

• Field of Research:

  Neurological Disease; Endocrinology

• Assay Protocol:

  https://www.medchemexpress.com/pitolisant.html

• Purity:

  99.73

• Solubility:

  DMSO : 200 mg/mL (ultrasonic)

• Smiles:

  ClC1=CC=C(CCCOCCCN2CCCCC2)C=C1

• Molecular Formula:

  C17H26ClNO

• Molecular Weight:

  295.85

• Precautions:

  H302, H315, H319, H335

• References & Citations:

  [1]Ligneau X, et al. BF2.649 [1-{3-[3- (4-Chlorophenyl) propoxy]propyl}piperidine, hydrochloride], a nonimidazole inverse agonist/antagonist at the human histamine H3 receptor: Preclinical pharmacology. J Pharmacol Exp Ther. 2007 Jan;320 (1) :365-75.|[2]Dudek M, et al. H3 histamine receptor antagonist pitolisant reverses some subchronic disturbances induced by olanzapine in mice. Metab Brain Dis. 2016 Oct;31 (5) :1023-9.|[3]Uguen M, et al. Preclinical evaluation of the abuse potential of Pitolisant, a histamine H? receptor inverse agonist/antagonist compared with Modafinil. Br J Pharmacol. 2013 Jun;169 (3) :632-44.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Reference compound1

• Clinical Information:

  Launched

• Isoform:

  H3 Receptor

• CAS Number:

  [362665-56-3]