Pitolisant-d5 (hydrochloride)

Pitolisant-d5 (hydrochloride)

• CAS Number: 2740634-42-6
• UNSPSC Description: Pitolisant-d5 hydrochloride (Ciproxidine-d5 hydrochloride) is the deuterium labeled Pitolisant hydrochloride (HY-12199B). Pitolisant hydrochloride is a potent and selective nonimidazole inverse agonist at the recombinant human histamine H3 receptor (Ki=0.16 nM)[1].
• Target Antigen: Histamine Receptor; Isotope-Labeled Compounds
• Type: Isotope-Labeled Compounds
• Related Pathways: GPCR/G Protein;Immunology/Inflammation;Neuronal Signaling;Others
• Field of Research: Endocrinology; Neurological Disease
• Smiles: ClC(C=C1)=CC=C1C([2H])C([2H])([2H])C([2H])([2H])OCCCN2CCCCC2.Cl
• Molecular Weight: 337.34
• References & Citations: [1]Ligneau X, et al. BF2.649 [1-{3-[3-(4-Chlorophenyl)propoxy]propyl}piperidine, hydrochloride], a nonimidazole inverse agonist/antagonist at the human histamine H3 receptor: Preclinical pharmacology. J Pharmacol Exp Ther. 2007 Jan;320(1):365-75.|[2]Dudek M, et al. H3 histamine receptor antagonist pitolisant reverses some subchronic disturbances induced by LY170053 in mice. Metab Brain Dis. 2016 Oct;31(5):1023-9.|[3]Uguen M, et al. Preclinical evaluation of the abuse potential of Pitolisant, a histamine H? receptor inverse agonist/antagonist compared with CRL 40476. Br J Pharmacol. 2013 Jun;169(3):632-44.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported