(E/Z) -Droloxifene

CAT: 0804-HY-121149B-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0804-HY-121149B-01Size:5 mg
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Description
(E/Z) -Droloxifene is a mixture of (E) -droloxifene (a selective estrogen receptor modulator) and (Z) -droloxifene. (E) -Droloxifene binds to the estrogen receptor (ER) with an IC50 value of 24 nM in rabbit uterine homogenates. (E) -Droloxifene increases uterine weight in immature rats, and reduces estradiol-induced increases in uterine weight in juvenile rats. (E) -Droloxifene also inhibits 17β-estradiol-stimulated growth of MCF-7, ZR-75-1, and T47D human breast cancer cells. (Z) -Droloxifene binds weakly to ER and has no estrogenic or antiestrogenic activity[1][2][3][4].
CAS Number
[165813-01-4]
Product Name Alternative
(E/Z) -3-Hydroxytamoxifen
UNSPSC
12352005
Target
Apoptosis; Estrogen Receptor/ERR
Related Pathways
Apoptosis; Vitamin D Related/Nuclear Receptor
Field of Research
Cancer
Smiles
OC1=CC=CC(/C(C2=CC=C(C=C2)OCCN(C)C)=C(CC)/C3=CC=CC=C3)=C1
Molecular Formula
C26H29NO2
Molecular Weight
387.51
References & Citations
[1]Robertson JF. Selective oestrogen receptor modulators/new antioestrogens: a clinical perspective. Cancer Treat Rev. 2004 Dec;30 (8) :695-706.|[2]Kawamura I, et al. The estrogenic and antiestrogenic activities of droloxifene in human breast cancers. Jpn J Pharmacol. 1993 Sep;63 (1) :27-34. |[3]Löser R, et al. Pharmacological activities of droloxifene isomers. Anticancer Res. 1988 Nov-Dec;8 (6) :1271-4.|[4]Hasmann M, et al. Preclinical data for Droloxifene. Cancer Lett. 1994 Sep 15;84 (2) :101-16.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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