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(E/Z) -Teriflunomide

CAT: 0804-HY-110159-01Size: 25 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-110159-01Size:25 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
(E/Z) -Teriflunomide ((E/Z) -A77 1726) is the active metabolite of Leflunomide. Leflunomide is an immunomodulatory agent that may exert effects by inhibiting the mitochondrial enzyme dihydroorotate dehydrogenase (DHODH). Leflunomide can be used for the research of rheumatoid arthritis (RA).
CAS Number
108605-62-5
Product Name Alternative
(E/Z) -A77 1726
UNSPSC
12352005
Hazard Statement
H301, H312, H330, H410
Target
Dihydroorotate Dehydrogenase
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
COVID-19-immunoregulation
Field of Research
Infection; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/e-z-teriflunomide.html
Purity
99.87
Solubility
DMSO : 50 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
C/C(O)=C(C#N)/C(NC1=CC=C(C(F)(F)F)C=C1)=O
Molecular Formula
C12H9F3N2O2
Molecular Weight
270.21
Precautions
H301, H312, H330, H410
References & Citations
[1]R I Fox, et al. Mechanism of action for leflunomide in rheumatoid arthritis. Clin Immunol. 1999 Dec;93 (3) :198-208.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Launched

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