(E/Z) -Teriflunomide

• Description :

  (E/Z) -Teriflunomide ((E/Z) -A77 1726) is the active metabolite of Leflunomide (HY-B0083) . Leflunomide is an immunomodulatory agent that may exert effects by inhibiting the mitochondrial enzyme dihydroorotate dehydrogenase (DHODH) . Leflunomide can be used for the research of rheumatoid arthritis (RA) [1].

• Product Name Alternative :

  (E/Z) -A77 1726

• UNSPSC :

  12352005

• Hazard Statement :

  H301, H312, H330, H410

• Target :

  Dihydroorotate Dehydrogenase

• Type :

  Reference compound

• Related Pathways :

  Metabolic Enzyme/Protease

• Applications :

  COVID-19-immunoregulation

• Field of Research :

  Infection; Inflammation/Immunology

• Assay Protocol :

  https://www.medchemexpress.com/e-z-teriflunomide.html

• Purity :

  99.87

• Solubility :

  DMSO : 50 mg/mL (ultrasonic; warming; heat to 60°C)

• Smiles :

  C/C(O)=C(C#N)/C(NC1=CC=C(C(F)(F)F)C=C1)=O

• Molecular Formula :

  C12H9F3N2O2

• Molecular Weight :

  270.21

• Precautions :

  H301, H312, H330, H410

• References & Citations :

  [1]R I Fox, et al. Mechanism of action for leflunomide in rheumatoid arthritis. Clin Immunol. 1999 Dec;93 (3) :198-208.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  Launched

• CAS Number :

  [108605-62-5]