Trofosfamide-d4

• Description :

  Trofosfamide-d4 is the deuterium labeled Trofosfamide. Trofosfamide is an orally bioavailable oxazaphosphorine derivative with antineoplastic activity[1][2].

• CAS Number :

  [1189884-36-3]

• UNSPSC :

  12352005

• Target :

  Bacterial; Isotope-Labeled Compounds

• Related Pathways :

  Anti-infection; Others

• Applications :

  Cancer-programmed cell death

• Field of Research :

  Cancer

• Solubility :

  10 mM in DMSO

• Smiles :

  N(CCCl)(CCCl)P1(=O)N(CCCl)C(C(CO1)([2H])[2H])([2H])[2H]

• Molecular Formula :

  C9H14D4Cl3N2O2P

• Molecular Weight :

  327.61

• References & Citations :

  [1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216.|[2]Witte HM, et al. Trofosfamide in the treatment of elderly or frail patients with diffuse large B-cell lymphoma. J Cancer Res Clin Oncol. 2019 Jan;145 (1) :129-136.|[3]Görn M, et al. A pilot study of docetaxel and trofosfamide as second-line 'metronomic' chemotherapy in the treatment of metastatic non-small cell lung cancer (NSCLC) . Onkologie. 2008 Apr;31 (4) :185-9.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Isotope-Labeled Compounds

• Clinical Information :

  No Development Reported