4010B-30

• Description:

  4010B-30 is a upregulator of apolipoprotein A-I (ApoA-I) . 4010B-30 regulates ApoA-I gene expression through activation of PPARγ. 4010B-30 promotes cholesterol efflux and ABCA1 expression. 4010B-30 protects against atherosclerotic lesion development in ApoE-/- mice[1][2].

• UNSPSC:

  12352005

• Hazard Statement:

  H302-H315-H319-H335

• Target:

  Apolipoprotein; ATP-binding cassette (ABC) transporters; PPAR

• Related Pathways:

  Cell Cycle/DNA Damage; Membrane Transporter/Ion Channel; Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor

• Field of Research:

  Cardiovascular Disease

• Smiles:

  O=C(C1=CC=C(F)C(C(F)(F)F)=C1)N2CC3(CCN(C)CC3)CC2

• Molecular Formula:

  C17H20F4N2O

• Molecular Weight:

  344.35

• Precautions:

  P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

• References & Citations:

  [1]Du Y, et al. A novel compound 4010B-30 upregulates apolipoprotein A-I gene expression through activation of PPARγ in HepG2 cells. Atherosclerosis. 2015 Apr;239 (2) :589-98.|[2]Hong, Bin et al. Effects of 4010B-30, A novel small molecule, on the endogenous apolipoprotein A-I expression and the development of atherosclerosis. Atherosclerosis, Volume 263, e74

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  [1415477-76-7]