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4010B-30

CAT: 0804-HY-117555Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-117555Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
4010B-30 is a upregulator of apolipoprotein A-I (ApoA-I) . 4010B-30 regulates ApoA-I gene expression through activation of PPARγ. 4010B-30 promotes cholesterol efflux and ABCA1 expression. 4010B-30 protects against atherosclerotic lesion development in ApoE-/- mice[1][2].
CAS Number
1415477-76-7
UNSPSC
12352005
Hazard Statement
H302-H315-H319-H335
Target
Apolipoprotein; ATP-binding cassette (ABC) transporters; PPAR
Related Pathways
Cell Cycle/DNA Damage; Membrane Transporter/Ion Channel; Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor
Field of Research
Cardiovascular Disease
Smiles
O=C(C1=CC=C(F)C(C(F)(F)F)=C1)N2CC3(CCN(C)CC3)CC2
Molecular Formula
C17H20F4N2O
Molecular Weight
344.35
Precautions
P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501
References & Citations
[1]Du Y, et al. A novel compound 4010B-30 upregulates apolipoprotein A-I gene expression through activation of PPARγ in HepG2 cells. Atherosclerosis. 2015 Apr;239 (2) :589-98.|[2]Hong, Bin et al. Effects of 4010B-30, A novel small molecule, on the endogenous apolipoprotein A-I expression and the development of atherosclerosis. Atherosclerosis, Volume 263, e74
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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