IDO1-IN-30

• Description:

  IDO1-IN-30 (Compound (R) -100) is a potent and highly selective IDO1 inhibitor. IDO1-IN-30 has an IC50 of 4.8 nM to IDO1 in SKOV3 cells. IDO1-IN-30 does not show significant cytotoxicity at 25 µM in HepG2 cells. IDO1-IN-30 can eliminate inhibition of CYP450 enzymes (such as 3A4, 2C9, 2D6) . IDO1-IN-30 can be used for research on cancer and inflammatory conditions[1].

• UNSPSC:

  12352005

• Target:

  Cytochrome P450; Indoleamine 2,3-Dioxygenase (IDO)

• Related Pathways:

  Metabolic Enzyme/Protease

• Field of Research:

  Cancer; Inflammation/Immunology

• Smiles:

  FC1=C(OC)C=C(F)C(N2N=NC([C@H](O)C3=C(N=CC4=CN=CN34)C5CC5)=C2)=C1

• Molecular Formula:

  C19H16F2N6O2

• Molecular Weight:

  398.37

• References & Citations:

  [1]Cren S, et al. Cellular Potency Optimization of Novel Heme-Binding Imidazo[5,1-b]thiazoles, Imidazo[1,5-a]pyridines and Pyrazines as Potent IDO1 Inhibitors Devoid of Cytochrome P450 Inhibition. J Med Chem. 2025 Oct 9;68 (19) :20130-20153.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  [2581050-29-3]