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IDO1-IN-30

CAT: 0804-HY-178479Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-178479Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
IDO1-IN-30 (Compound (R) -100) is a potent and highly selective IDO1 inhibitor. IDO1-IN-30 has an IC50 of 4.8 nM to IDO1 in SKOV3 cells. IDO1-IN-30 does not show significant cytotoxicity at 25 µM in HepG2 cells. IDO1-IN-30 can eliminate inhibition of CYP450 enzymes (such as 3A4, 2C9, 2D6) . IDO1-IN-30 can be used for research on cancer and inflammatory conditions[1].
CAS Number
2581050-29-3
UNSPSC
12352005
Target
Cytochrome P450; Indoleamine 2,3-Dioxygenase (IDO)
Related Pathways
Metabolic Enzyme/Protease
Field of Research
Cancer; Inflammation/Immunology
Smiles
FC1=C(OC)C=C(F)C(N2N=NC([C@H](O)C3=C(N=CC4=CN=CN34)C5CC5)=C2)=C1
Molecular Formula
C19H16F2N6O2
Molecular Weight
398.37
References & Citations
[1]Cren S, et al. Cellular Potency Optimization of Novel Heme-Binding Imidazo[5,1-b]thiazoles, Imidazo[1,5-a]pyridines and Pyrazines as Potent IDO1 Inhibitors Devoid of Cytochrome P450 Inhibition. J Med Chem. 2025 Oct 9;68 (19) :20130-20153.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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