GSI-136

• Description:

  GSI-136 is an inhibitor of γ-secretase with an IC50 of 3 nM. GSI-136 can lead to a dose-dependent reduction of Aβ40 levels in diethylamine-extracted brain homogenates of C57BL/6 mice. GSI-136 can be studied in medicinal chemistry and Alzheimer's disease research[1].

• UNSPSC:

  12352005

• Target:

  γ-secretase

• Related Pathways:

  Neuronal Signaling; Stem Cell/Wnt

• Applications:

  Neuroscience-Neurodegeneration

• Field of Research:

  Neurological Disease

• Smiles:

  O=S(C1=CC=C(S1)Cl)(N[C@H](CO)C(CC)CC)=O

• Molecular Formula:

  C11H18ClNO3S2

• Molecular Weight:

  311.85

• References & Citations:

  [1]Chinthakindi, P. K., et al., (2017) . Sulfonimidamides in Medicinal and Agricultural Chemistry. Angewandte Chemie (International ed. in English), 56 (15), 4100-4109. |[2]Sehgelmeble, F., et al., (2012) . Sulfonimidamides as sulfonamides bioisosteres: rational evaluation through synthetic, in vitro, and in vivo studies with γ-secretase inhibitors. ChemMedChem, 7 (3), 396-399.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  Phase 1

• CAS Number:

  [443989-01-3]