GSI-136

CAT: 0804-HY-117236Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-117236Size:1 Each
Selected
PRICE
AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Product image 1
1 / 1
Description
GSI-136 is an inhibitor of γ-secretase with an IC50 of 3 nM. GSI-136 can lead to a dose-dependent reduction of Aβ40 levels in diethylamine-extracted brain homogenates of C57BL/6 mice. GSI-136 can be studied in medicinal chemistry and Alzheimer's disease research[1].
CAS Number
[443989-01-3]
UNSPSC
12352005
Target
γ-secretase
Related Pathways
Neuronal Signaling; Stem Cell/Wnt
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Smiles
O=S(C1=CC=C(S1)Cl)(N[C@H](CO)C(CC)CC)=O
Molecular Formula
C11H18ClNO3S2
Molecular Weight
311.85
References & Citations
[1]Chinthakindi, P. K., et al., (2017) . Sulfonimidamides in Medicinal and Agricultural Chemistry. Angewandte Chemie (International ed. in English), 56 (15), 4100-4109. |[2]Sehgelmeble, F., et al., (2012) . Sulfonimidamides as sulfonamides bioisosteres: rational evaluation through synthetic, in vitro, and in vivo studies with γ-secretase inhibitors. ChemMedChem, 7 (3), 396-399.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Phase 1

Related Products

CatalogName
HY-164451GSI-18
HY-145428BT-GSI
HY-P2553Histone H3 (116-136), C116-136
HY-169982EGFR-IN-136
HY-19319-01MI-136
HY-N15169BG-136
HY-119490UMB-136
HY-14573-01SJG-136
HY-W1127089-01Antifungal agent 136
HY-161180-01Antitumor agent-136

Alternative Products

CatalogName
MF-0138377-01GSI-136
MF-0146744-01BT-GSI
MF-0142486-01GSI-18
MBS6089524-01GSI-953
MBS578766DAPT (GSI-IX)
MBS386673-01Begacestat (GSI-953)
012979GSI-953 discontinued
GR107047GSI MTS Assay Kit
GR107052GSI CDC Assay Kit
GR107046GSI MTT Assay Kit

Popular Products