GSI-18

• Description :

  GSI-18 is a γ-secretase inhibitor with anticancer activity. GSI-18 inhibits the attachment-free growth of pancreatic cancer cells by inhibiting Notch signaling[1].

• UNSPSC :

  12352100

• Target :

  Notch; γ-secretase

• Type :

  Reference compound

• Related Pathways :

  Neuronal Signaling; Stem Cell/Wnt

• Applications :

  Neuroscience-Neurodegeneration

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/gsi-18.html

• Smiles :

  O=S(N[C@H]1[C@@]2([H])CC3=CC=CC=C3C[C@]1([H])CC2)(C4=CC=CS4)=O

• Molecular Formula :

  C17H19NO2S2

• Molecular Weight :

  333.47

• References & Citations :

  [1]Mullendore, et al. "Ligand-dependent Notch signaling is involved in tumor initiation and tumor maintenance in pancreatic cancer." Clinical Cancer Research 15.7 (2009) : 2291-2301.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [362653-62-1]