GSI-18

• Description:

  GSI-18 is a γ-secretase inhibitor with anticancer activity. GSI-18 inhibits the attachment-free growth of pancreatic cancer cells by inhibiting Notch signaling[1].

• UNSPSC:

  12352100

• Target:

  Notch; γ-secretase

• Type:

  Reference compound

• Related Pathways:

  Neuronal Signaling; Stem Cell/Wnt

• Applications:

  Neuroscience-Neurodegeneration

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/gsi-18.html

• Smiles:

  O=S(N[C@H]1[C@@]2([H])CC3=CC=CC=C3C[C@]1([H])CC2)(C4=CC=CS4)=O

• Molecular Formula:

  C17H19NO2S2

• Molecular Weight:

  333.47

• References & Citations:

  [1]Mullendore, et al. "Ligand-dependent Notch signaling is involved in tumor initiation and tumor maintenance in pancreatic cancer." Clinical Cancer Research 15.7 (2009) : 2291-2301.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  [362653-62-1]