Avenanthramide A-d4

• Description:

  Avenanthramide A-d4 is the deuterium labeled Avenanthramide A (HY-114977) . Avenanthramide A is a phytoalexin, which can be found in oats (Avena sativa L.) . Avenanthramide A targets the RNA helicase DDX3, leads to mitochondrial swelling and increased ROS production, and induces apoptosis in CRC cells. Avenanthramide A exhibits antitumor efficacy in mouse model. Avenanthramide A orally active[1].

• UNSPSC:

  12352005

• Target:

  Apoptosis; Isotope-Labeled Compounds; Reactive Oxygen Species (ROS)

• Related Pathways:

  Apoptosis; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB; Others

• Field of Research:

  Cancer

• Smiles:

  O=C(C1=CC(O)=CC=C1NC(/C=C/C2=C([2H])C([2H])=C(C([2H])=C2[2H])O)=O)O

• Molecular Formula:

  C16H9D4NO5

• Molecular Weight:

  303.30

• References & Citations:

  [1]Fu R, et al., Avenanthramide A triggers potent ROS-mediated anti-tumor effects in colorectal cancer by directly targeting DDX3. Cell Death Dis. 2019 Aug 7;10 (8) :593.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Isotope-Labeled Compounds

• Clinical Information:

  No Development Reported