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Avenanthramide A

CAT: 0804-HY-114977-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0804-HY-114977-01Size:5 mg
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Description
Avenanthramide A is a phytoalexin, which can be found in oats (Avena sativa L.) . Avenanthramide A targets the RNA helicase DDX3, leads to mitochondrial swelling and increased ROS production, and induces apoptosis in CRC cells. Avenanthramide A exhibits antitumor efficacy in mouse model. Avenanthramide A orally active[1].
CAS Number
[108605-70-5]
Product Name Alternative
Monobromobimane
UNSPSC
12352005
Hazard Statement
H302
Target
Apoptosis; Reactive Oxygen Species (ROS)
Type
Natural Products
Related Pathways
Apoptosis; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/avenanthramide-a.html
Purity
98.35
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(C1=CC(O)=CC=C1NC(/C=C/C2=CC=C(C=C2)O)=O)O
Molecular Formula
C16H13NO5
Molecular Weight
299.28
Precautions
H302
References & Citations
[1]Fu R, et al., Avenanthramide A triggers potent ROS-mediated anti-tumor effects in colorectal cancer by directly targeting DDX3. Cell Death Dis. 2019 Aug 7;10 (8) :593.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Natural Products
Clinical Information
No Development Reported

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