RS-0406

• Description:

  RS-0406 is a beta-sheet breaker targeting Amyloid-β. RS-0406 can inhibits Aβ (1-42) fibrillogenesis and protect against Aβ (1-42) -induced cytotoxicity in primary hippocampal neurons. RS-0406 can be used for the research of neurological disease, such as Alzheimer's disease (AD) [1].

• UNSPSC:

  12352005

• Target:

  Amyloid-β

• Related Pathways:

  Neuronal Signaling

• Field of Research:

  Neurological Disease

• Smiles:

  OC1=CC=CC(NC2=NN=C(NC3=CC(O)=CC=C3)C=C2)=C1

• Molecular Formula:

  C16H14N4O2

• Molecular Weight:

  294.31

• References & Citations:

  [1]Nakagami Y, et al. A novel beta-sheet breaker, RS-0406, reverses amyloid beta-induced cytotoxicity and impairment of long-term potentiation in vitro. Br J Pharmacol. 2002 Nov;137 (5) :676-82.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  530112-00-6