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AL-1

CAT: 0804-HY-114809Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-114809Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
AL-1 is a potent O2- generation inhibitor (IC50 = 7.6 μM) through the inhibition of leukocytic NADPH oxidase. AL-1 inhibits 12-O-Tetradecanoylphorbol-13-acetate (TPA) -induced H2O2 production. AL-1 reduces tumor incidence in ICR mouse skin. AL-1 can be used for research on oxidative stress-related diseases including cancer[1].
CAS Number
126455-04-7
UNSPSC
12352005
Target
NADPH Oxidase; Reactive Oxygen Species (ROS)
Related Pathways
Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB
Applications
COVID-19-anti-virus
Field of Research
Cancer; Inflammation/Immunology
Smiles
CC#CC#C/C=C1[C@]2([H])[C@](O2)([H])[C@@]3(CC[C@@H](CO3)OC(CC(C)C)=O)O\1
Molecular Formula
C19H22O5
Molecular Weight
330.37
References & Citations
[1]Nakamura Y, et al. A diacetylenic spiroketal enol ether epoxide, AL-1, from Artemisia lactiflora inhibits 12-O-tetradecanoylphorbol-13-acetate-induced tumor promotion possibly by suppression of oxidative stress. Cancer Lett. 1999 Jun 1;140 (1-2) :37-45.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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