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ErSO-DFP

CAT: 0804-HY-144070-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-144070-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
ErSO-DFP is an anticipatory unfolded protein response (a-UPR) activator. ErSO-DFP has enhanced selectivity for estrogen receptor alpha-positive (ERα+) cancer cells with a wider selectivity window than ErSO. ErSO-DFP displays antitumor activity against MCF-7 in mice. ErSO-DFP can cross the blood brain barrier[1].
CAS Number
2768139-76-8
UNSPSC
12352005
Target
Estrogen Receptor/ERR
Type
Reference compound
Related Pathways
Vitamin D Related/Nuclear Receptor
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/erso-dfp.html
Purity
99.56
Solubility
DMSO : ≥ 100 mg/mL
Smiles
O=C1NC2=C(C=CC=C2[C@]1(N3CCC(F)(CC3)F)C4=CC=C(C=C4)O)C(F)(F)F
Molecular Formula
C20H17F5N2O2
Molecular Weight
412.35
References & Citations
[1]Matthew W Boudreau, et al. Activators of the Anticipatory Unfolded Protein Response with Enhanced Selectivity for Estrogen Receptor Positive Breast Cancer. J Med Chem. 2022 Mar 10;65 (5) :3894-3912.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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