NVP-ABE171

CAT: 0804-HY-114052Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-114052Size:1 Each
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Description
NVP-ABE171 is an efficient, long-lasting and orally active PDE4 inhibitor with IC50 values for PDE4D, PDE4B, PDE4A and PDE4C of 1.5, 34, 602 and 1230 nM respectively. NVP-ABE171 enhances the cAMP accumulation induced by isoproterenol, inhibits the oxidative burst of eosinophils and the release of inflammatory cytokines from T cells and monocytes. NVP-ABE171 exhibits potent anti-inflammatory activity in animal models of asthma and pulmonary inflammation. NVP-ABE171 can be used for research on asthma and chronic obstructive pulmonary disease[1].
CAS Number
[426268-06-6]
UNSPSC
12352005
Target
Phosphodiesterase (PDE)
Related Pathways
Metabolic Enzyme/Protease
Field of Research
Inflammation/Immunology
Smiles
O=C(O)C1=CC=C(C2=NC(C3=CC4=NON=C4C=C3)=C5N=CC=CC5=C2)C=C1
Molecular Formula
C21H12N4O3
Molecular Weight
368.34
References & Citations
[1]Trifilieff A, et al. Pharmacological profile of a novel phosphodiesterase 4 inhibitor, 4- (8-benzo[1,2,5]oxadiazol-5-yl-[1,7]naphthyridin-6-yl) -benzoic acid (NVP-ABE171), a 1,7-naphthyridine derivative, with anti-inflammatory activities. J Pharmacol Exp Ther. 2002 Apr;301 (1) :241-8.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
PDE4

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