PYD-106

• Description :

  PYD-106 is a stereoselective pyrrolidinone (PYD) positive allosteric modulator for GluN2C-containing NMDA receptors. PYD-106 increases opening frequency and open time of single channel currents activated by maximally effective concentrations of agonist but only has modest effects on glutamate and glycine EC50. PYD-106 selectively enhances the responses of diheteromeric GluN1/GluN2C receptors but not triheteromeric GluN1/GluN2A/GluN2C receptors[1].

• Product Name Alternative :

  CB-5945; ADL-5945

• UNSPSC :

  12352005

• Target :

  IGluR

• Type :

  Reference compound

• Related Pathways :

  Membrane Transporter/Ion Channel; Neuronal Signaling

• Applications :

  Neuroscience-Neurodegeneration

• Field of Research :

  Neurological Disease

• Assay Protocol :

  https://www.medchemexpress.com/pyd-106.html

• Purity :

  98.13

• Solubility :

  DMSO : 125 mg/mL (ultrasonic)

• Smiles :

  O=C(OC)C1=CC=C(C(C(C(C)=O)=C2O)N(CCC3=C(C)NC4=C3C=CC=C4)C2=O)C=C1

• Molecular Formula :

  C25H24N2O5

• Molecular Weight :

  432.47

• References & Citations :

  [1]Khatri A, et al. Structural determinants and mechanism of action of a GluN2C-selective NMDA receptor positive allosteric modulator. Mol Pharmacol. 2014;86 (5) :548-560.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  NMDA Receptor

• CAS Number :

  [1560894-05-4]