7β-Hydroxycholesterol (Standard)

CAT: 0804-HY-113341RSize: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-113341RSize:1 Each
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Description
7β-Hydroxycholesterol (Standard) is the analytical standard of 7β-Hydroxycholesterol. This product is intended for research and analytical applications. 7β-Hydroxycholesterol is an oxysterol that derived by the oxidation of cholesterol. 7β-hydroxycholesterol can induce cellular oxidative stress, apoptosis, and necrosis, resulting in cytotoxicity. 7β-hydroxycholesterol has antitumor activity[1][2][3][4].
CAS Number
[566-27-8]
UNSPSC
12352100
Target
Apoptosis; Interleukin Related; Reactive Oxygen Species (ROS) ; Reference Standards
Related Pathways
Apoptosis; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB; Others
Field of Research
Cancer; Inflammation/Immunology; Neurological Disease; Cardiovascular Disease
Smiles
CC(C)CCC[C@@H](C)[C@H]1CC[C@@]2([H])[C@]3([H])[C@@H](O)C=C4C[C@@H](O)CC[C@]4(C)[C@@]3([H])CC[C@]12C
Molecular Formula
C27H46O2
Molecular Weight
402.65
References & Citations
[1]Anne Vejux, et al. 7-Ketocholesterol and 7β-hydroxycholesterol: In vitro and animal models used to characterize their activities and to identify molecules preventing their toxicity. Biochem Pharmacol. 2020 Mar;173:113648.|[2]Lemaire S, et al. Different patterns of IL-1beta secretion, adhesion molecule expression and apoptosis induction in human endothelial cells treated with 7alpha-, 7beta-hydroxycholesterol, or 7-ketocholesterol. FEBS Lett. 1998 Dec 4;440 (3) :434-9.|[3]Lizard G, et al. Characterization and comparison of the mode of cell death, apoptosis versus necrosis, induced by 7beta-hydroxycholesterol and 7-ketocholesterol in the cells of the vascular wall. Arterioscler Thromb Vasc Biol. 1999 May;19 (5) :1190-200.|[4]Roussi S, et al. Different apoptotic mechanisms are involved in the antiproliferative effects of 7beta-hydroxysitosterol and 7beta-hydroxycholesterol in human colon cancer cells. Cell Death Differ. 2005 Feb;12 (2) :128-35.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards

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