7ß-Hydroxycholesterol-d7

• Description:

  7ß-Hydroxycholesterol-d7 is the deuterium labeled 7α-Hydroxycholesterol. 7β-Hydroxycholesterol is an oxysterol that derived by the oxidation of cholesterol. 7β-hydroxycholesterol can induce cellular oxidative stress, apoptosis, and necrosis, resulting in cytotoxicity. 7β-hydroxycholesterol has antitumor activity[1][2].

• UNSPSC:

  12352211

• Target:

  Apoptosis; Interleukin Related; Isotope-Labeled Compounds

• Type:

  Isotope-Labeled Compounds

• Related Pathways:

  Apoptosis; Immunology/Inflammation; Others

• Field of Research:

  Cancer; Inflammation/Immunology; Neurological Disease; Cardiovascular Disease

• Purity:

  97.0

• Solubility:

  DMF : ≥ 2mg/mL|DMSO : ≥ 0.1mg/mL|Ethanol : ≥ 20mg/mL

• Smiles:

  C[C@@]12[C@](CC[C@]2([H])[C@H](C)CCCC(C([2H])([2H])[2H])([2H])C([2H])([2H])[2H])([H])[C@@]3([H])[C@@](CC1)([H])[C@@]4(C(C[C@H](CC4)O)=C[C@@H]3O)C

• Molecular Formula:

  C27H39D7O2

• Molecular Weight:

  409.70

• References & Citations:

  [1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216.|[2]Anne Vejux, et al. 7-Ketocholesterol and 7β-hydroxycholesterol: In vitro and animal models used to characterize their activities and to identify molecules preventing their toxicity. Biochem Pharmacol. 2020 Mar;173:113648.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Isotope-Labeled Compounds

• Clinical Information:

  No Development Reported

• CAS Number:

  [349553-97-5]