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AR-9281 (Standard)

CAT: 0804-HY-111151R-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-111151R-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
AR-9281 (Standard) is the analytical standard of AR-9281. This product is intended for research and analytical applications. AR9281 (APAU) is a potent, selective and orally active soluble epoxide hydrolase (s-EH) inhibitor. AR-9281 can inhibits human sEH (HsEH) and murine sEH (MsEH) with IC50 values of 13.8 nM and 1.7 nM, respectively. AR9281 can be used for the research of inflammation, hypertension and type 2 diabetes[1][2].
CAS Number
913548-29-5
UNSPSC
12352100
Target
Epoxide Hydrolase; Reference Standards
Related Pathways
Metabolic Enzyme/Protease; Others
Field of Research
Infection; Metabolic Disease; Cardiovascular Disease
Smiles
O=C(NC1(C2)CC3CC2CC(C3)C1)NC4CCN(C(C)=O)CC4
Molecular Formula
C18H29N3O2
Molecular Weight
319.44
References & Citations
[1]Fangyu Du, et al. Discovery of memantyl urea derivatives as potent soluble epoxide hydrolase inhibitors against lipopolysaccharide-induced sepsis. Eur J Med Chem. 2021 Nov 5;223:113678. |[2]Kathleen Guglielmino, et al. Pharmacological inhibition of soluble epoxide hydrolase provides cardioprotection in hyperglycemic rats. Am J Physiol Heart Circ Physiol. 2012 Oct 1;303 (7) :H853-62.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards

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