SPK-843

• Description:

  SPK-843 is an antifungal agent. SPK-843 shows inhibitory activity against A. fumigatus MF-13, A. flavus TIMM 0057, and A. niger TIMM 2814 with MICs of 0.5 μg/mL, 0.25 μg/mL, and 0.0625 μg/mL, respectively. SPK-843 exhibits dose-dependent efficacy in murine models of pulmonary aspergillosis. SPK-843 can be used for the research of related fungal infections[1].

• Product Name Alternative:

  SPA-S-753 (free base)

• UNSPSC:

  12352005

• Target:

  Fungal

• Related Pathways:

  Anti-infection

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Infection

• Smiles:

  O=C([C@H]1[C@@](C[C@H](/C=C/C=C/C=C/C=C/C=C/C=C/C=C/[C@H](C)[C@]([C@@H](C)CCC(O)CC(C2=CC=C(NC)C=C2)=O)([H])OC3=O)O[C@@](O[C@H](C)[C@@H](O)[C@@H]4NC(CN(C)C)=O)([H])[C@H]4O)([H])O[C@](O)(C[C@H](C[C@H](C[C@H](C[C@H](CC(C[C@H](C3)O)=O)O)O)O)O)C[C@@H]1O)NCCN(C)C

• Molecular Formula:

  C67H103N5O19

• Molecular Weight:

  1282.56

• References & Citations:

  [1]Kakeya H, et al. Efficacy of SPK-843, a novel polyene antifungal, in comparison with amphotericin B, liposomal amphotericin B, and micafungin against murine pulmonary aspergillosis. Antimicrob Agents Chemother. 2008 May;52 (5) :1868-70.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  [143483-67-4]