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SG-210

CAT: 0804-HY-106915Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-106915Size:1 Each
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Description
SG-210 (SPR 210) is an orally active and selective aldose reductase (AR) inhibitor. SG-210 has IC50 values of 9.5 nM and 10 nM for AR from porcine lens and human placenta, respectively. SG-210 can inhibit sorbitol accumulation and ameliorate diabetic neuropathy and retinopathy in Streptozotocin (HY-13753) -induced diabetic rats. SG-210 can be used in the research of diseases such as diabetes-related complications[1].
CAS Number
[143162-65-6]
Product Name Alternative
SPR 210
UNSPSC
12352005
Target
Aldose Reductase
Related Pathways
Metabolic Enzyme/Protease
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Metabolic Disease; Neurological Disease
Smiles
O=C1N(CC2=NC3=C(S2)C(F)=CC(F)=C3F)C4=CC=CC=C4SC1CC(O)=O
Molecular Formula
C18H11F3N2O3S2
Molecular Weight
424.42
References & Citations
[1]Matsui T, et al. Pharmacological profiles of a novel aldose reductase inhibitor, SPR-210, and its effects on streptozotocin-induced diabetic rats. Jpn J Pharmacol. 1994 Feb;64 (2) :115-24.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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