ML-210

• Description :

  ML-210 is a selective and covalent glutathione peroxidase 4 (GPX4) inhibitor with an EC50 of 30 nM. ML-210 binds the GPX4 selenocysteine residue. ML-210 has anti-cancer activity[1][2].

• UNSPSC :

  12352005

• Hazard Statement :

  H302, H413

• Target :

  Ferroptosis; Glutathione Peroxidase

• Type :

  Reference compound

• Related Pathways :

  Apoptosis; Metabolic Enzyme/Protease

• Applications :

  Cancer-programmed cell death

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/ml-210.html

• Purity :

  99.93

• Solubility :

  DMSO : 25 mg/mL (ultrasonic)

• Smiles :

  O=C(N1CCN(C(C2=CC=C(Cl)C=C2)C3=CC=C(Cl)C=C3)CC1)C4=NOC(C)=C4[N+]([O-])=O

• Molecular Formula :

  C22H20Cl2N4O4

• Molecular Weight :

  475.32

• Precautions :

  H302, H413

• References & Citations :

  [1]John K. Eaton, et al. Targeting a Therapy-Resistant Cancer Cell State Using Masked Electrophiles as GPX4 Inhibitors. Biorxiv. 2018.|[2]Weïwer M, et al. Development of small-molecule probes that selectively kill cells induced to express mutant RAS. Bioorg Med Chem Lett. 2012 Feb 15;22 (4) :1822-6.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  GPX4

• CAS Number :

  [1360705-96-9]