ML-210

CAT: 0804-HY-100003-01Size: 1 mgDry Ice: NoHazardous: No
CAT#:0804-HY-100003-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
ML-210 is a selective and covalent glutathione peroxidase 4 (GPX4) inhibitor with an EC50 of 30 nM. ML-210 binds the GPX4 selenocysteine residue. ML-210 has anti-cancer activity[1][2].
CAS Number
[1360705-96-9]
UNSPSC
12352005
Hazard Statement
H302, H413
Target
Ferroptosis; Glutathione Peroxidase
Type
Reference compound
Related Pathways
Apoptosis; Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/ml-210.html
Purity
99.93
Solubility
DMSO : 25 mg/mL (ultrasonic)
Smiles
O=C(N1CCN(C(C2=CC=C(Cl)C=C2)C3=CC=C(Cl)C=C3)CC1)C4=NOC(C)=C4[N+]([O-])=O
Molecular Formula
C22H20Cl2N4O4
Molecular Weight
475.32
Precautions
H302, H413
References & Citations
[1]John K. Eaton, et al. Targeting a Therapy-Resistant Cancer Cell State Using Masked Electrophiles as GPX4 Inhibitors. Biorxiv. 2018.|[2]Weïwer M, et al. Development of small-molecule probes that selectively kill cells induced to express mutant RAS. Bioorg Med Chem Lett. 2012 Feb 15;22 (4) :1822-6.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
GPX4

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