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(±) 19 (20) -EDP Ethanolamide

CAT: 0931-T35468-01Size: 25 µgDry Ice: NoHazardous: No
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CAT#:0931-T35468-01Size:25 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
2123485-34-5
Target
Others, Interleukin
Related Pathways
Others, Immunology/Inflammation
Bioactivity
(±) 19 (20) -EDP ethanolamide is an ω-3 endocannabinoid epoxide and cannabinoid (CB) receptor agonist (EC50s = 108 and 280 nM for CB1 and CB2, respectively) . It is produced through direct epoxygenation of docosahexaenoyl ethanolamide by cytochrome P450 (CYP) epoxygenases. (±) 19 (20) -EDP ethanolamide (25 μM) reduces the viability of 143B metastatic osteosarcoma cells. It decreases the production of IL-6 and increases the production of IL-10 when used at concentrations ranging from 2.5 to 10 μM in BV-2 microglia stimulated by LPS and decreases LPS-induced cytotoxicity when used at concentrations ranging from 5 to 10 μM. It also decreases nitrite production when used at a concentration of 7.5 μM, an effect that can be partially reversed by the CB2 receptor antagonist AM630 and the PPARγ antagonist GW 9662 . (±) 19 (20) -EDP ethanolamide induces vasodilation of isolated preconstricted bovine coronary arteries (ED50 = 1.9 μM) and reduces tube formation by human microvascular endothelial cells (HMVECs) in a Matrigel assay.
Smiles
CCC1OC1C\C=C/C\C=C/C\C=C/C\C=C/C\C=C/CCC(=O)NCCO
Molecular Formula
C24H37NO3
Molecular Weight
387.564
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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