BCX-5

• Description :

  BCX-5 (PD 141955) is an orally active inhibitor of purine nucleoside phosphorylase (PNP) with a Ki of 0.08 μM. BCX-5 can inhibit cell proliferation and mixed lymphocyte reaction. BCX-5 can increase plasma inosine and guanosine levels. BCX-5 can be used for the research of immunology[1][2].

• CAS Number :

  [132138-76-2]

• Product Name Alternative :

  PD 141955

• UNSPSC :

  12352005

• Target :

  Nucleoside Antimetabolite/Analog

• Related Pathways :

  Cell Cycle/DNA Damage

• Field of Research :

  Inflammation/Immunology

• Smiles :

  O=C(NC(N)=N1)C2=C1C(CC3=CSC=C3)=CN2

• Molecular Formula :

  C11H10N4OS

• Molecular Weight :

  246.29

• References & Citations :

  [1]Gilbertsen RB, et al. Comparative in vitro and in vivo activities of two 9-deazaguanine analog inhibitors of purine nucleoside phosphorylase, CI-972 and PD 141955. Biochem Pharmacol. 1992 Sep 1;44 (5) :996-9.|[2]Wilburn DJ, et al. PD 141955 and CI-972: 9-deazaguanine analog purine nucleoside phosphorylase inhibitors. I. Suppression of the human mixed lymphocyte reaction (MLR) . Agents Actions. 1993;39 Spec No:C96-8.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported