AH 6809 (Standard)

CAT: 0804-HY-10418R-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0804-HY-10418R-01Size:5 mg
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Description
AH 6809 (Standard) is the analytical standard of AH 6809. This product is intended for research and analytical applications. AH 6809 is an antagonist of EP and DP receptor, with Kis of 1217, 1150, 1597, and 1415 nM for the cloned human EP1, EP2, EP3-III, and DP receptor respectively. AH 6809 has a Ki of 350 nM for mouse EP2 receptor[1][2][3].
CAS Number
[33458-93-4]
UNSPSC
12352005
Target
Prostaglandin Receptor; Reference Standards
Related Pathways
GPCR/G Protein; Others
Field of Research
Inflammation/Immunology; Endocrinology
Smiles
O=C1C2=C(C=CC(C(O)=O)=C2)OC3=CC(OC(C)C)=CC=C31
Molecular Formula
C17H14O5
Molecular Weight
298.29
References & Citations
[1]Abramovitz M, et, al. The utilization of recombinant prostanoid receptors to determine the affinities and selectivities of prostaglandins and related analogs. Biochim Biophys Acta. 2000 Jan 17;1483 (2) :285-93.|[2]Kiriyama M, et, al. Ligand binding specificities of the eight types and subtypes of the mouse prostanoid receptors expressed in Chinese hamster ovary cells. Br J Pharmacol. 1997 Sep;122 (2) :217-24.|[3]Woodward DF, et, al. 6-Isopropoxy-9-oxoxanthene-2-carboxylic acid (AH 6809), a human EP2 receptor antagonist. Biochem Pharmacol. 1995 Nov 9;50 (10) :1731-3.|[4]Zoccal KF, et, al. Opposing roles of LTB4 and PGE2 in regulating the inflammasome-dependent scorpion venom-induced mortality. Nat Commun. 2016 Feb 23;7:10760.|[5]Keery RJ, et, al. AH6809, a prostaglandin DP-receptor blocking drug on human platelets. Br J Pharmacol. 1988 Jul;94 (3) :745-54.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards

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